The Parkinson’s Sub-Study explores whether regular “pedal-n-play” neuro-exergaming with iPACES can support brain health for people living with Parkinson’s disease. This year-long study involves exercising with iPACES at home using your smartphone, completing brief cognitive activities, and attending three half-day, in-person evaluation visits at a study site.

Participation in this sub-study does not replace the Main Study — it adds to it. To join the Parkinson’s Sub-Study, you must first be eligible for and enroll in the iPACES Main Study. The Parkinson’s Sub-Study includes everything required in the Main Study plus in-person visits and condition-specific assessments.

Eligibility Summary

To qualify, you must:

• Be 50 years of age or older
• Have a diagnosis of Parkinson’s disease and experience Parkinson’s symptoms
• Live near one of our three study sites (We have sites in the Albany Capital District, NY; on the North Shore of Boston, MA; and in the greater Los Angeles area, CA)

And you must be able and willing to:

• Exercise with iPACES at least 3 times per week for 20–30 minutes per session
• Use a smartphone to complete questionnaires and short cognitive tests
• Attend three in-person, half-day evaluations (when you start the study, 6 months into the study, and 1 year into the study)

Study Equipment

Participants who do not already have compatible equipment can be provided with the equipment needed to pedal-n-play at home (funded by an NIH/NINDS grant). This may include a recumbent bike, a cadence meter, and a smartwatch to track activity and heart rate.