New study examines effects of simultaneous physical and cognitive exercise on brain health
Our study, which is currently enrolling participants, is called the “iPACES Clinical Trial 2021.” This study plans to implement our interactive Physical and Cognitive Exercise System (iPACES), consisting of an under-the-desk elliptical, tablet, smart watch, and heart rate monitor, into 120 homes. We ask our participants to fill out questionnaires, complete a variety of mentally challenging tasks, and exercise with the iPACES for at least 20 minutes 3 times a week, slowly building up to 45 minutes 5 times a week. We will then compare cognitive and biomarker outcomes from one-year of treatment intervention to synchronous, but non-interactive physical and cognitive exercise. We aim to enroll 120, co-residing MCI-caregiver pairs and both partners will need to participate in this study.
iPACES LLC is developing an innovative solution that utilizes Neuro-Exergaming to address the challenges of Alzheimer’s disease and related dementias (ADRDs). Dementia cases are on the rise, and in the absence of a cure, the devastating impact has led to increased calls for expanded research. Behavioral interventions, such as exercise, have been noted to enhance brain health and can be useful in the prevention and remediation of cognitive decline, as in mild cognitive impairment (MCI). iPACES LLC aims to develop the next iteration of Neuro-Exergaming for the prevention and remediation of decline due to ADRDs through a clinical trial of the interactive Physical and Cognitive Exercise System (iPACES v3).
Thanks to the grant awarded to iPACES LLC by the National Institute on Aging under the auspices of the Small Business Innovation Research (SBIR) program and National Institutes of Health (NIH), this clinical trial has been made possible. During this current clinical trial, iPACES LLC aims to enhance long-term exercise as a treatment by adding a variety of interesting and stimulating Neuro-Exergames to promote adherence, coupled with the integration of assessments with remote data capture and updated versions of the game. The research will be conducted in an in-home clinical trial with MCI-caregiver pairs. We aim to compare cognitive and biomarker outcomes from one-year of treatment intervention with one-year of synchronous, but non-interactive physical and cognitive exercise. We hope to follow this investigation with preparation of results for publication and use in commercialization.
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iPACES is developing a neuro-exergame for use in clinical research.
Our current study is a completely remote study.
No, we provide it to you free of charge.
iPACES principals have been published in leading scientific journals and publications in recent years.
Journal of Clinical Medicine
The Enhanced Interactive Physical and Cognitive and Exercise System (iPACES v2.0): Pilot Clinical Trial
Abstract: Given increasing longevity worldwide, older adults and caregivers are seeking ways to curb cognitive decline especially for those with mild cognitive impairment (MCI, now mild neurocognitive disorder, mNCD, Diagnostic and Statistical Manual of Mental Disorders, 5th ed. (DSM-V). This quasi-experimental, within-subjects pilot clinical trial was designed to replicate and extend the study of cognitive benefits for MCI by improving upon our prior interactive Physical and Cognitive Exercise Study (iPACES v1.0) by increasing the usability of the neuro-exergame and exploring possible underlying neurobiological mechanisms. Older adults were enrolled in a three-month, in-home trial of a portable neuro-exergame (iPACES™ v2.0) where participants pedaled and steered along a virtual bike path (Memory Lane™). Neuropsychological function was assessed at baseline after component familiarization intervals (e.g., two weeks of exercise-only, game-only, etc.) and after three months of interactive neuro-exergame intervention. Fourteen participants were enrolled in the study and seven completed the final evaluation. Intent-to-treat analyses were conducted with imputed missing data (total n = 14). Significant improvement in executive function (Stroop) was found (d = 0.68, p = 0.02) only. Changes in salivary biomarkers (cortisol and insulin-like growth factor 1; IGF-1) were significantly associated with improved cognition. Further research is needed, but pilot data suggest that a portable in-home neuro-exergame may be an additional, practical tool to fight back against cognitive decline and dementia.
Clinical Interventions in Aging
The interactive Physical and Cognitive Exercise System (iPACES): effects of a 3-month in-home pilot clinical trial for mild cognitive impairment and caregivers
Background: Alzheimer’s and related dementias are on the rise, and older adults and their families are seeking accessible and effective ways to stave off or ameliorate mild cognitive impairment (MCI). Aim: This pilot clinical trial (ClinicalTrials.gov Identifier: 03069391) examined neuropsychological and neurobiological outcomes of interactive physical and mental exercise. Participants and methods: Older adults (MCI and caregivers) were enrolled in a 3-month, in-home trial of a portable neuro-exergame (the interactive Physical and Cognitive Exercise System [iPACESTM]), in which they pedaled and steered along a virtual bike path to complete a list of errands (Memory LaneTM). Neuropsychological function and salivary biomarkers were measured at pre-, mid-, and posttrial. Ten older adults complied with the recommended use of iPACES (complete dose; $2×/wk, 67% of the 15 who also had pre- and postevaluation data). Statistical analyses compared change over time and also change among those with a complete dose vs inadequate dose. Correlations between change in neuropsychological and biomarker measures were also examined. Results: Executive function and verbal memory increased after 3 months (p = 0.01; no significant change was found with an inadequate dose). Change in salivary biomarkers was moderately associated with increasing cognition (cortisol, r = 0.68; IGF-1, r = 0.37). Conclusion: Further research is needed, but these pilot data provide preliminary indications to suggest neuro-exergaming can impact cognitive function, perhaps via neurobiological mechanisms, and as such may provide an effective and practical way to promote healthy aging.
Journal of Aging and Physical Activity
Neuropsychological Benefits of Neuro-Exergaming for Older Adults: A Pilot Study of an Interactive Physical and Cognitive Exercise System (iPACES)
Dementia cases are on the rise and researchers seek innovative ways to prevent or ameliorate cognitive impairment in later life. Some research
has reported that combining mental and physical exercise may benefit cognition more than either alone. This randomized pilot trial examined
the feasibility and cognitive benefit for older adults (n = 30) of a single bout of neuro-exergaming (physical activity with cognitive training)
using an interactive physical and cognitive exercise system (iPACES), compared with that of exergaming or neurogaming alone. Intent-to-treat
and sensitivity analyses were conducted using repeated-measures ANOVA, controlling for age, sex, and education. A significant interaction
effect was found for executive function (Color Trails 2), with a significant improvement in the neuro-exergaming condition. Results dem-
onstrate feasibility for older adults to use a novel and theoretically-derived neuro-exergame, and also provide promising new evidence that
neuro-exergaming can yield greater cognitive benefit than either of its component parts.
Handbook of Nutraceuticals and Functional Foods
Protein as a Functional Food Source
Obesity continues to plague our society as a major public health issue. The latest obesity prevalence statistics show over 70% of U.S. adults are overweight and 40% of U.S. adults and 20% of youth are obese. Unfortunately, the prevalence of obesity among non-Hispanic blacks and Hispanic adults is even higher at 47%.1 Healthcare costs associated with obesity-related disease are in excess of $190 billion per year.2,3 In addition, the economic impact expands past healthcare costs and includes indirect costs associated with wages lost due to employee absenteeism, decreased work productivity, poor academic performance, impaired cognition, and low morale both in the present and future. These staggering numbers clearly highlight the necessity for immediate intervention among all groups and ages of our population. While progress has occurred in illuminating certain pathways controlling energy homeostasis,4,5 scientific advances have thus far failed to prevent the worldwide spread of obesity. The current definition of overweight for an adult is a BMI between 25–29.9 kg/m2 and for obese ≥30 kg/m2.